Toothpaste evaluation two: Haoyikang’s “fluoride-free” concept marketing has a mystery

In this era of “looking at the face”, a white and neat “middle-class tooth” has become the standard hardware of high-end people. A good tooth is not only a personal health requirement, but also a social necessity. How to choose a toothpaste for daily oral cleaning?

In October 2014, Consumer Reports sent 6 brands of toothpaste such as Colgate, Crest, Haoyikang, Zhonghua, Negro, and Tian Qi to a third-party authoritative testing agency, in addition to detecting their friction values (see “Six Brands of Toothpaste Evaluation Report 1: Tian Qi toothpaste has a high friction value and long-term improper use has greater tooth wear”), and at the same time tested health and safety indicators such as effective fluorine, total fluoride content, and triclosan.

The test results showed that the available fluoride content of 6 brands of toothpastes was at a similar level, and the other two products that claimed to be fluoride-free also met their nominal levels. In addition, the potentially carcinogenic antibacterial triclosan, which has attracted much attention this year, has not been detected in these products.

Is fluoride toothpaste toxic?

In the second half of this year, Haoyikang Fe bio-efficacy toothpaste began large-scale advertising, and its packaging also marked “this product fluoride-free formula, drug-free, pregnant women and children can use it with confidence” – this seems to imply that consumers: fluoride toothpaste, pregnant women and children can not use it with confidence.

Among the domestic toothpastes, Tian Qi special effect Chinese medicine toothpaste is also marked with the word “fluoride-free” on the packaging.

What is the difference between fluorine and fluorine-free? Is fluorine free safer?

In 1945, the United States first added fluoride to toothpaste to produce the world’s first fluoride toothpaste. Because of its excellent anti-moth effect, it has been greatly promoted around the world.

“Fluoride can directly inhibit bacterial growth in the mouth. Combined with the surface of the tooth, it enhances the resistance of the tooth to corrosion and has the effect of preventing decay. For the site of tooth decay lesions, it can also play a role in restoring remineralization. Moreover, higher concentrations of fluorine can also directly kill caries-causing bacteria and other bacteria. Zheng Wei, an engineer at the National Light Industry Toothpaste Wax Products Quality Supervision and Testing Center, said in an interview with Consumer Report.

So what are the dangers of fluoride toothpaste?

In 2008, some domestic media reprinted an article in Scientific American magazine, “Dangerous Fluoride Toothpaste”. The title of this article does not match, and it is not mainly about the dangers of fluoride toothpaste, but about the problem of excessive fluoride intake. However, in the subsequent transmission, there is no mention that many places in the United States are the background of high-fluoride areas, and the focus is on the fact that excessive fluoride intake can cause “neurological diseases, endocrine diseases and even cancer”.

In this regard, Arrail Dental general practitioner Hong Sheng told this reporter that it is not necessary to publicize the harm of fluorine too much in China.

“For a small number of high-fluoride areas in China, such as the Yunnan-Guizhou Plateau or the northwest region, because the water already contains a lot of fluoride, there is indeed a hidden concern of excessive intake. However, for most areas, this problem does not exist, and fluoride toothpaste can be used safely. He said.

“And the latest research from the American Dental Association shows that fluoride can be used to strengthen teeth when a child grows his first tooth.” Hong Sheng added.

Dr. Nie Yukai of Xi’an Beilin Guoxing Stomatological Hospital also said: “The promotion of the concept of fluorine-free is that the department manufacturers are clearly confused, and the anti-moth effect of fluorine is very certain, and the research in the medical field is not as good as the marketing concept of the business, and it is rarely subverted.” ”

China’s 2008 version of the “toothpaste” standard stipulates that the effective fluoride and total fluoride content limits of children’s toothpaste are 0.05%-0.11%, and the effective fluoride and total fluoride limits of adult toothpaste are 0.05%-0.15%.

“The reason why the standard sets two fluoride indicators is because fluoride in toothpaste easily reacts with components such as calcium carbonate to form precipitates, thereby losing its effectiveness. Therefore, in the total fluorine content, there are precipitated fluorine and available fluorine. The total amount of fluorine exceeding the upper limit is dangerous, and the available fluorine content is within the safe range, the higher the mothproof effect. Zheng Wei pointed out.

The test results of 7 products of 6 brands sent by this journal show that the two toothpastes of Haoyikang and Tianqi do not contain fluoride as claimed.

The two children’s toothpastes of Black and Colgate both had 0.06% available fluoride. Among the other three adult toothpastes, the effective fluoride content of China Superior Multi-Care Toothpaste reached the highest limit of 0.15%, while Crest Total 7 had the lowest effect of 0.13%, and the difference between different toothpastes was only 0.01%. (as shown below)

How to prevent moths without fluorine?

In this test, the two toothpastes of Tian Qi and Haoyikang were promoted as “fluoride-free”. Previously, Tianqi toothpaste manufacturer Aoqili Company said that fluorine-free products are mainly aimed at high-fluoride disease areas in China. The fluoride-free of Haoyikang lies in its addition of “lysozyme”, which is said to “kill” more than 400 kinds of bacteria in the mouth.

How does lysozyme achieve the effect of sterilization? Is it better than fluoride toothpaste?

Xu Xueqing, associate professor of microbiology and biochemical pharmacy at the School of Pharmacy of Southern Medical University, told this reporter: “Lysozyme is an efficient and stable protein, which achieves the effect of sterilization by hydrolyzing bacterial cell walls. The substance has a good decomposition effect on gram-positive bacteria (a large group of bacteria). ”

In the “FE Biological Efficacy Clinical Trial Report” issued by the Shanghai Stomatological Hospital Research Institute, it is said that Haoyikang toothpaste has antibacterial, anti-calculus, anti-moth and other effects.

However, during the investigation, our reporter learned that although lysozyme is efficient and stable, it is easy to lose activity and stability in a more alkaline environment. The pH value of Haoyikang Fe biological lysozyme toothpaste tested this time was 8.24, which was weakly alkaline.

Tong Yu, director of the technical department of Jiangsu Snow Leopard Daily Chemical Co., Ltd., a manufacturer of Haoyikang, explained to this journal: “After long-term research by Fudan University and us, Fudan University and we use relevant technology to superimpose a layer of ‘protective agent’ on the outside of ‘FE complex protein lysozyme’, which can make the ‘enzyme’ maintain the stability of the toothpaste paste for a long time, so the stability of the ‘enzyme’ under alkaline conditions is no problem at all.” ”

“pH 7 is not a very harsh condition, pH between 4-8, lysozyme can maintain 80%-90% of the active factor.” Xu Xueqing explained. However, he said that lysozyme is only a protein and cannot remineralize like fluorine.

Tong Yu also said: “The so-called remineralization is the moth-proof feature of fluoride toothpaste, and FE biological lysozyme toothpaste achieves the effect of preventing moth by eliminating dental plaque, and there is no remineralization effect.” ”

In order to understand the relevant research of lysozyme, the reporter contacted the School of Life Sciences of Fudan University, and the relevant staff informed that the intellectual property rights of FE lysozyme were sold more than 20 years ago, and Professor Li Zhixun of the R&D team had already retired for more than 10 years. It is reported that Shanghai Hi-Tech Biological Products Co., Ltd. also used Fe lysozyme into lozenges as early as 1999. This is not a new technology.

Comprehensive evaluation Colgate, China is better

In August this year, the Hong Kong Consumer Council conducted a random inspection of 35 toothpastes from 23 brands on the market and found that 3 ordinary toothpastes, including Colgate, were found to contain or carcinogenic preservatives triclosan. This has once again brought triclosan, whose safety is still uncertain, to the forefront.

In order to provide consumers with accurate information, the toothpaste sent for inspection this time also included triclosan in the test, and the test results showed that 7 toothpastes did not contain triclosan, and consumers could use it with peace of mind.

Based on the test results of this laboratory, Consumer Reports gave a comprehensive evaluation of 7 toothpastes, among which Colgate Anti-Cavity Insistence Children’s Toothpaste and China Outstanding Effect Double Care performed better, while Tianqi Special Effect Chinese Medicine Toothpaste performed poorly. (See comprehensive scoring table)

[Special note: Consumer Reports welcomes media reprint, but test results cannot be used for commercial publicity without authorization]

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